Absolutely! We have lots of Shapeoko users out there that use Vectric software with their Shapeoko CNC Router.
Unless you already own Vectric, we recommend that you start with our Carbide Create CAD/CAM software. Carbide Create does everything that most users need, and we include it for free with all Carbide 3D machines. Because we wrote it, we're able to support it and help you get started.
If you choose Vectric, it will work well, we just won't be able to support you with it.